8q5r
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==HpARI bound to mouse IL-33== | |
| - | + | <StructureSection load='8q5r' size='340' side='right'caption='[[8q5r]], [[Resolution|resolution]] 2.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8q5r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Heligmosomoides_polygyrus_bakeri Heligmosomoides polygyrus bakeri] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8Q5R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8Q5R FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> |
| - | [[Category: Higgins | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8q5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8q5r OCA], [https://pdbe.org/8q5r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8q5r RCSB], [https://www.ebi.ac.uk/pdbsum/8q5r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8q5r ProSAT]</span></td></tr> |
| - | [[Category: Jamwal | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/IL33_MOUSE IL33_MOUSE] Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury. In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets. This form is rapidely lost upon angiogenic or proinflammatory activation. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Heligmosomoides polygyrus bakeri]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Higgins MK]] | ||
| + | [[Category: Jamwal A]] | ||
Revision as of 08:33, 9 May 2024
HpARI bound to mouse IL-33
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