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8yx1
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==CD40 in complex with Bleselumab Fab== | |
| - | + | <StructureSection load='8yx1' size='340' side='right'caption='[[8yx1]], [[Resolution|resolution]] 2.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8yx1]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8YX1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8YX1 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8yx1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8yx1 OCA], [https://pdbe.org/8yx1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8yx1 RCSB], [https://www.ebi.ac.uk/pdbsum/8yx1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8yx1 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/TNR5_HUMAN TNR5_HUMAN] Defects in CD40 are the cause of immunodeficiency with hyper-IgM type 3 (HIGM3) [MIM:[https://omim.org/entry/606843 606843]. A rare immunodeficiency syndrome characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE. It results in a profound susceptibility to bacterial infections.<ref>PMID:11675497</ref> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TNR5_HUMAN TNR5_HUMAN] Receptor for TNFSF5/CD40LG. | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Caaveiro JMM]] | ||
| + | [[Category: Fernandez-Perez J]] | ||
| + | [[Category: Tsumoto K]] | ||
Current revision
CD40 in complex with Bleselumab Fab
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