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1rju

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[[Image:1rju.gif|left|200px]]
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{{STRUCTURE_1rju| PDB=1rju | SCENE= }}
{{STRUCTURE_1rju| PDB=1rju | SCENE= }}
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'''Crystal structure of a truncated form of yeast copper thionein'''
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===Crystal structure of a truncated form of yeast copper thionein===
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==Overview==
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We report here the crystal structure of yeast copper thionein (Cu-MT), determined at 1.44-A resolution. The Cu-MT structure shows the largest known oligonuclear Cu(I) thiolate cluster in biology, consisting of six trigonally and two digonally coordinated Cu(I) ions. This is at variance with the results from previous spectroscopic determinations, which were performed on MT samples containing seven rather than eight metal ions. The protein backbone has a random coil structure with the loops enfolding the copper cluster, which is located in a cleft where it is bound to 10 cysteine residues. The protein structure is somewhat different from that of Ag(7)-MT and similar, but not identical, to that of Cu(7)-MT. Besides the different structure of the metal cluster, the main differences lie in the cysteine topology and in the conformation of some portions of the backbone. The present structure suggests that Cu-MT, in addition to its role as a safe depository for copper ions in the cell, may play an active role in the delivery of copper to metal-free chaperones.
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The line below this paragraph, {{ABSTRACT_PUBMED_15613489}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15613489 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15613489}}
==About this Structure==
==About this Structure==
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[[Category: Mangani, S.]]
[[Category: Mangani, S.]]
[[Category: Weser, U.]]
[[Category: Weser, U.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:35:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:32:58 2008''

Revision as of 20:33, 27 July 2008

Image:1rju.png

Template:STRUCTURE 1rju

Crystal structure of a truncated form of yeast copper thionein

Template:ABSTRACT PUBMED 15613489

About this Structure

1RJU is a Single protein structure. Full crystallographic information is available from OCA.

Reference

The crystal structure of yeast copper thionein: the solution of a long-lasting enigma., Calderone V, Dolderer B, Hartmann HJ, Echner H, Luchinat C, Del Bianco C, Mangani S, Weser U, Proc Natl Acad Sci U S A. 2005 Jan 4;102(1):51-6. Epub 2004 Dec 21. PMID:15613489

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