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1rl0

From Proteopedia

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[[Image:1rl0.gif|left|200px]]
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{{STRUCTURE_1rl0| PDB=1rl0 | SCENE= }}
{{STRUCTURE_1rl0| PDB=1rl0 | SCENE= }}
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'''Crystal structure of a new ribosome-inactivating protein (RIP): dianthin 30'''
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===Crystal structure of a new ribosome-inactivating protein (RIP): dianthin 30===
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==Overview==
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Ribosome inactivating proteins (RIPs) are plant proteins with enzymatic activity identified as rRNA N-glycosidase (EC 3.2.2.22), which cleaves the N-glycosidic bond of a specific adenine on the ricin/sarcin region of rRNA, thus causing inhibition of protein synthesis. They also depurinate extensively DNA and other polynucleotides. The three-dimensional structure of dianthin 30, a type 1 (single-chain) RIP of Dianthus caryophyllus (leaves), is now described at 1.4 angstroms, a resolution never achieved before for any RIP. The fold typical of RIPs is conserved, despite some differences in the loop regions. The general structure comparison by superimposed alpha-carbon (249 atoms) and the sequence alignment by structure for dianthin 30 and saporin-S6 give a root mean square deviation of 0.625 angstroms. Despite the differences reported for the biological activities of the two RIPs, their structures fit quite well and both show a protein segment containing strands beta7, beta8, and beta9 shorter than other RIPs. However, the surface electrostatic potential in the active site region neatly distinguishes dianthin 30 from saporin-S6. The possible relationship between the charge distribution and the behavior of the proteins toward different substrates is discussed.
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The line below this paragraph, {{ABSTRACT_PUBMED_15681236}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15681236 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15681236}}
==About this Structure==
==About this Structure==
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[[Category: Alpha and beta region]]
[[Category: Alpha and beta region]]
[[Category: Mixed beta-sheet]]
[[Category: Mixed beta-sheet]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:37:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:14:10 2008''

Revision as of 13:14, 27 July 2008

Image:1rl0.png

Template:STRUCTURE 1rl0

Crystal structure of a new ribosome-inactivating protein (RIP): dianthin 30

Template:ABSTRACT PUBMED 15681236

About this Structure

1RL0 is a Single protein structure of sequence from Dianthus caryophyllus. Full crystallographic information is available from OCA.

Reference

The 1.4 anstroms structure of dianthin 30 indicates a role of surface potential at the active site of type 1 ribosome inactivating proteins., Fermani S, Falini G, Ripamonti A, Polito L, Stirpe F, Bolognesi A, J Struct Biol. 2005 Feb;149(2):204-12. PMID:15681236

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