User:Chloe Tucker/Sandbox 1
From Proteopedia
(Difference between revisions)
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=== Binding/Active Site of GIPR with GIP === | === Binding/Active Site of GIPR with GIP === | ||
[[Image:GIP_last_pic.png|350 px|right|thumb|Figure 1. Residue Interactions with GIP]] | [[Image:GIP_last_pic.png|350 px|right|thumb|Figure 1. Residue Interactions with GIP]] | ||
| - | <scene name='10/1038815/Active_site/1'>GIP | + | <scene name='10/1038815/Active_site/1'>GIP binding site</scene> |
=== Binding/Active Site of GIPR with Tirzepatide === | === Binding/Active Site of GIPR with Tirzepatide === | ||
[[Image:TZ_last_pic.png|350 px|right|thumb|Figure 2. Residue Interactions with Tirzepatide]] | [[Image:TZ_last_pic.png|350 px|right|thumb|Figure 2. Residue Interactions with Tirzepatide]] | ||
| - | <scene name='10/1038815/Tirzepatide_active_site/2'>Tirzepatide | + | The <scene name='10/1038815/Tirzepatide_active_site/2'>Tirzepatide binding site</scene> is the same as GIP with the N-term binding to the extracellular membrane. |
| + | The <scene name='10/1038815/Tirzepatide_residues/1'>residues</scene> are mostly the same just in a different conformation that is allowing for more hydrogen bonding. | ||
Revision as of 14:05, 11 April 2024
GIP and GIP-R
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References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
- ↑ Sun B, Willard FS, Feng D, Alsina-Fernandez J, Chen Q, Vieth M, Ho JD, Showalter AD, Stutsman C, Ding L, Suter TM, Dunbar JD, Carpenter JW, Mohammed FA, Aihara E, Brown RA, Bueno AB, Emmerson PJ, Moyers JS, Kobilka TS, Coghlan MP, Kobilka BK, Sloop KW. Structural determinants of dual incretin receptor agonism by tirzepatide. Proc Natl Acad Sci U S A. 2022 Mar 29;119(13):e2116506119. PMID:35333651 doi:10.1073/pnas.2116506119
Student Contributors
- Chloe Tucker
- Mandy Bechman
