User:Chloe Tucker/Sandbox 1
From Proteopedia
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This is a sample scene created with SAT to of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | This is a sample scene created with SAT to of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
=== Binding/Active Site of GIPR with GIP === | === Binding/Active Site of GIPR with GIP === | ||
| - | [[Image: | + | [[Image:GIP_hydrogen_bonds.jpg|350 px|right|thumb|Figure 1. Residue Interactions with GIP]] |
The <scene name='10/1038815/Overview/3'>active site</scene> of GIP with the GIP receptor is where the N-term of GIP binds with the extracellular membrane of the GIP receptor. | The <scene name='10/1038815/Overview/3'>active site</scene> of GIP with the GIP receptor is where the N-term of GIP binds with the extracellular membrane of the GIP receptor. | ||
The <scene name='10/1038815/Active_site/1'>residues</scene> within the active site are forming hydrogen bonds with each other and activating the G-protein to start signalling. | The <scene name='10/1038815/Active_site/1'>residues</scene> within the active site are forming hydrogen bonds with each other and activating the G-protein to start signalling. | ||
Revision as of 14:37, 11 April 2024
GIP and GIP-R
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References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
- ↑ Sun B, Willard FS, Feng D, Alsina-Fernandez J, Chen Q, Vieth M, Ho JD, Showalter AD, Stutsman C, Ding L, Suter TM, Dunbar JD, Carpenter JW, Mohammed FA, Aihara E, Brown RA, Bueno AB, Emmerson PJ, Moyers JS, Kobilka TS, Coghlan MP, Kobilka BK, Sloop KW. Structural determinants of dual incretin receptor agonism by tirzepatide. Proc Natl Acad Sci U S A. 2022 Mar 29;119(13):e2116506119. PMID:35333651 doi:10.1073/pnas.2116506119
Student Contributors
- Chloe Tucker
- Mandy Bechman
