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Introduction

Function

Figure 1. DPPIV structure

DPPIV, a moonlighting protein, has been implicated in many functions and diseases of the body including glucose metabolism, cardiovascular disease, the stress response, autoimmune diseases (ie HIV/AIDS), inflammation, and tumor biology.

Catalytic Triad

The Catalytic Triad of DPP4 is Ser630, His740, Asp708.

Mechanism

Figure 2. DPPIV Mechanism

The mechanism for the truncation of GLP-1 using DPP4 is a covalent catalysis. 708 1st Nucleophile is Oxygen on Ser630 and the 2nd Nucleophile is water.

Disease

Relevance

Structural highlights

sheets and light sky blue and helices are light green

"cystine rich region" 351-506

Caveolin-1 binding site (ADA) 201-210 and See 630

________

catalytic domain (medium sea green) 552-776 beta-propeller (tomato) 56-496 cytosine rich (khaki) 351-506

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