Tau-tubulin kinase

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== Function ==
== Function ==
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Tau-tubulin kinase (TTBK) phosphorylates microtubule-associated protein tau and tubulin<ref>PMID:24808823</ref>. TTBK contains 2 isomers: TTBK1 and TTBK2 which are expressed in different tissues. TTBK1 and TTBK2 are homologous in their catalytic domains with identical catalytic residues, but different in their non-catalytic domains. TTBK2 serves a critical function in cilia genesis<ref>PMID:25950000</ref>.
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'''Tau-tubulin kinase''' (TTBK) phosphorylates microtubule-associated protein tau and tubulin<ref>PMID:24808823</ref>. TTBK contains 2 isomers: '''TTBK1''' and '''TTBK2''' which are expressed in different tissues. TTBK1 and TTBK2 are homologous in their catalytic domains with identical catalytic residues, but different in their non-catalytic domains. TTBK2 serves a critical function in cilia genesis<ref>PMID:25950000</ref>.
== Disease ==
== Disease ==

Current revision

Human tau-tubulin kinase kinase domain complex with inhibitor, glycerol, sulfate and dimethyl sulfoxide (PDB code 4btm)

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Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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