Solute carrier family 12
From Proteopedia
(Difference between revisions)
(New page: <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> == Function == '''Solute carrier family 12 member 2''' (NKCC 2) is a Na+/K+/Cl- cotr...) |
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<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | ||
== Function == | == Function == | ||
| - | '''Solute carrier family 12 member 2''' (NKCC 2) is a Na+/K+/Cl- cotransporter across membranes, involved in chloride transport, metal ion transport and positive regulation of cell volume. NKCCs play a vial role in the regulation of ionic balance. NKCCs utilize the existing Na+ and K+ gradients to move Cl- into or out of cells<ref>PMID:320819471</ref>. | + | '''Solute carrier family 12 member 2''' (NKCC 2) is a Na+/K+/Cl- cotransporter across membranes, involved in chloride transport, metal ion transport and positive regulation of cell volume. NKCCs play a vial role in the regulation of ionic balance. NKCCs utilize the existing Na+ and K+ gradients to move Cl- into or out of cells<ref>PMID:320819471</ref>. '''NKCC 4''' mediates the couple movement of K+ and Cl- ions across the plasma membrane. |
== Disease == | == Disease == | ||
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| + | Mutations in '''NKCC 3''' play pathogenic effects in Gitelman syndrome<ref>PMID:35591852</ref>. | ||
== Relevance == | == Relevance == | ||
Revision as of 08:28, 17 April 2024
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References
- ↑ . PMID:320819471
- ↑ Li N, Gu HF. Genetic and Biological Effects of SLC12A3, a Sodium-Chloride Cotransporter, in Gitelman Syndrome and Diabetic Kidney Disease. Front Genet. 2022 May 3;13:799224. PMID:35591852 doi:10.3389/fgene.2022.799224
