Solute carrier family 12

Function

Solute carrier family 12 member 2 (NKCC 2) is a Na+/K+/Cl- cotransporter across membranes, involved in chloride transport, metal ion transport and positive regulation of cell volume. NKCCs play a vial role in the regulation of ionic balance. NKCCs utilize the existing Na+ and K+ gradients to move Cl- into or out of cells^[1]. NKCC 4 mediates the couple movement of K+ and Cl- ions across the plasma membrane.

Disease

Mutations in NKCC 3 play pathogenic effects in Gitelman syndrome^[2]. Polymorphism in NKCC 3 contribute to genetic susceptibility to diabetic nephropathy and essential hypertension^[3].

Relevance

Structural highlights

This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.