Solute carrier family 12

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Revision as of 13:28, 18 April 2024

Dimer of human solute carrier family 12 member 2 complex with K+ (purple) and Cl- (green) ions (PDB code 7mxo)

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↑ . PMID:320819471
↑ Li N, Gu HF. Genetic and Biological Effects of SLC12A3, a Sodium-Chloride Cotransporter, in Gitelman Syndrome and Diabetic Kidney Disease. Front Genet. 2022 May 3;13:799224. PMID:35591852 doi:10.3389/fgene.2022.799224
↑ . Correction to: SLC12A2 variants cause a neurodevelopmental disorder or cochleovestibular defect. Brain. 2023 Apr 19;146(4):e26. PMID:36670515 doi:10.1093/brain/awad012
↑ Kim JH, Shin HD, Park BL, Moon MK, Cho YM, Hwang YH, Oh KW, Kim SY, Lee HK, Ahn C, Park KS. SLC12A3 (solute carrier family 12 member [sodium/chloride] 3) polymorphisms are associated with end-stage renal disease in diabetic nephropathy. Diabetes. 2006 Mar;55(3):843-8. PMID:16505253 doi:10.2337/diabetes.55.03.06.db05-1013
↑ Howard HC, Mount DB, Rochefort D, Byun N, Dupré N, Lu J, Fan X, Song L, Rivière JB, Prévost C, Horst J, Simonati A, Lemcke B, Welch R, England R, Zhan FQ, Mercado A, Siesser WB, George AL Jr, McDonald MP, Bouchard JP, Mathieu J, Delpire E, Rouleau GA. The K-Cl cotransporter KCC3 is mutant in a severe peripheral neuropathy associated with agenesis of the corpus callosum. Nat Genet. 2002 Nov;32(3):384-92. PMID:12368912 doi:10.1038/ng1002
↑ Moseng MA, Su CC, Rios K, Cui M, Lyu M, Glaza P, Klenotic PA, Delpire E, Yu EW. Inhibition mechanism of NKCC1 involves the carboxyl terminus and long-range conformational coupling. Sci Adv. 2022 Oct 28;8(43):eabq0952. PMID:36306358 doi:10.1126/sciadv.abq0952

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	== Structural highlights ==		== Structural highlights ==

-	'''NKCC 2''' cotransports Na+, K+, Cl- in the molar ration of 1:1:2. The 3D structure of NKCC 2 complex with these ions show only K+ and one Cl- ion. K+ interacts with sidechain of Y383, 4 ~~main chain carbonyl~~ atoms and with Cl- ion <ref>PMID:36306358</ref>.	+	'''NKCC 2''' cotransports Na+, K+, Cl- in the molar ration of 1:1:2. The 3D structure of NKCC 2 complex with these ions show only K+ and one Cl- ion. <scene name='10/1043562/Cv/4'>K+ interacts with sidechain of Y383, 4 mainchain oxygen atoms and with Cl- ion</scene><ref>PMID:36306358</ref>.