User:Lily Lindemann/Sandbox1
From Proteopedia
(Difference between revisions)
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=== Diabetes and Obesity === | === Diabetes and Obesity === | ||
[[Image:pathway.png|300 px|left|thumb|Nonfucnctional Pathway due to Type II Diabetes]] | [[Image:pathway.png|300 px|left|thumb|Nonfucnctional Pathway due to Type II Diabetes]] | ||
| - | Type II Diabetes is when the pancreas does not produce enough insulin for the body.[https://www.mayoclinic.org/diseases-conditions/diabetes/symptoms-causes/syc-20371444] This in turn makes the blood glucose level dangerously low. When the sugar levels in our blood become too low people can become dizzy and tired. On the other hand, when blood sugar levels become too high then can become feverish and sick. | + | Type II Diabetes is when the pancreas does not produce enough insulin for the body.[https://www.mayoclinic.org/diseases-conditions/diabetes/symptoms-causes/syc-20371444] This in turn makes the blood glucose level dangerously low. When the sugar levels in our blood become too low people can become dizzy and tired. On the other hand, when blood sugar levels become too high then can become feverish and sick. The decrease in blood sugar can be related to a decrease in GLP-1 within the body. |
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| - | The ligand uses <scene name='10/1038821/Pi_stacking_hormone_receptor/2'>pi stacking</scene> (tryptophan) and hydrophilic interactions to dock into the receptor. | + | The ligand uses <scene name='10/1038821/Pi_stacking_hormone_receptor/2'>pi stacking</scene> (tryptophan) and hydrophilic interactions at the N-terminus to dock into the receptor. |
=== Drug Interactions === | === Drug Interactions === | ||
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== Relevance == | == Relevance == | ||
| - | Tirzepatide and other GLP-1R related antagonist drugs help to regulate blood glucose levels.[https://health.clevelandclinic.org/mounjaro-for-weight-loss] Although these drugs can make remarkable changes, the long term effects of GLP-1R related drugs are unknown. There have been some hints toward thyroid cancers but this was only shown in mice during trial periods. | + | Tirzepatide and other GLP-1R related antagonist drugs help to regulate blood glucose levels.[https://health.clevelandclinic.org/mounjaro-for-weight-loss] The GLP-1R antagonists are able to aid the body in proper secretion of insulin because the antagonists are harder for the body to break down. Although these drugs can make remarkable changes, the long term effects of GLP-1R related drugs are unknown. There have been some hints toward thyroid cancers but this was only shown in mice during trial periods. |
Revision as of 23:18, 22 April 2024
Glucagon-Like Peptide 1 Receptor (GLP1-R)
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