1h0h
From Proteopedia
(New page: 200px<br /> <applet load="1h0h" size="450" color="white" frame="true" align="right" spinBox="true" caption="1h0h, resolution 1.80Å" /> '''TUNGSTEN CONTAINING...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1H0H is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Desulfovibrio_gigas Desulfovibrio gigas]] with CA, 2MD, MGD, S, SF4 and EPE as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1H0H OCA]]. | + | 1H0H is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Desulfovibrio_gigas Desulfovibrio gigas]] with CA, 2MD, MGD, S, SF4 and EPE as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: WA. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1H0H OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: tungsten selenium formate dehydrogenase]] | [[Category: tungsten selenium formate dehydrogenase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:53:59 2007'' |
Revision as of 09:49, 30 October 2007
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TUNGSTEN CONTAINING FORMATE DEHYDROGENASE FROM DESULFOVIBRIO GIGAS
Overview
Desulfovibrio gigas formate dehydrogenase is the first representative of a, tungsten-containing enzyme from a mesophile that has been structurally, characterized. It is a heterodimer of 110 and 24 kDa subunits. The large, subunit, homologous to E. coli FDH-H and to D. desulfuricans nitrate, reductase, harbors the W site and one [4Fe-4S] center. No small subunit, ortholog containing three [4Fe-4S] clusters has been reported. The, structural homology with E. coli FDH-H shows that the essential residues, (SeCys158, His159, and Arg407) at the active site are conserved. The, active site is accessible via a positively charged tunnel, while product, release may be facilitated, for H(+) by buried waters and protonable amino, acids and for CO(2) through a hydrophobic channel.
About this Structure
1H0H is a [Protein complex] structure of sequences from [Desulfovibrio gigas] with CA, 2MD, MGD, S, SF4 and EPE as [ligands]. Structure known Active Site: WA. Full crystallographic information is available from [OCA].
Reference
Gene sequence and the 1.8 A crystal structure of the tungsten-containing formate dehydrogenase from Desulfovibrio gigas., Raaijmakers H, Macieira S, Dias JM, Teixeira S, Bursakov S, Huber R, Moura JJ, Moura I, Romao MJ, Structure. 2002 Sep;10(9):1261-72. PMID:12220497
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