Integrator complex
From Proteopedia
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== Function == | == Function == | ||
| - | '''Integrator complex''' (Int) is a protein complex which induces termination at loci transcribed by RNA polymerase II. Multiple Int subunits coordinate effective termination<ref>PMID:36634676</ref>. | + | '''Integrator complex''' (Int) is a protein complex which induces termination at loci transcribed by RNA polymerase II. Multiple Int subunits coordinate effective termination<ref>PMID:36634676</ref>. Int consists of 14 subunits some of which act as RNA endonuclease and are essential for small nuclear RNA biogenesis<ref>PMID:32800671</ref> |
== Disease == | == Disease == | ||
Revision as of 10:07, 24 April 2024
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References
- ↑ Wagner EJ, Tong L, Adelman K. Integrator is a global promoter-proximal termination complex. Mol Cell. 2023 Feb 2;83(3):416-427. PMID:36634676 doi:10.1016/j.molcel.2022.11.012
- ↑ Mendoza-Figueroa MS, Tatomer DC, Wilusz JE. The Integrator Complex in Transcription and Development. Trends Biochem Sci. 2020 Nov;45(11):923-934. PMID:32800671 doi:10.1016/j.tibs.2020.07.004
