Sandbox Ben Whiteside

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 29: Line 29:
In order to restore basal amylin levels in mice, researchers have performed PEGylation, the addition of poly ethylene glycol, to amylin within residues 1-11 of the peptide, most likely at the two amine groups of K1<ref name="Guerreiro">PMID: 23818080</ref>. Administration of the modified amylin in mice showed evidence of reduced glycemia and prolonged action compared to endogenous amylin <ref name="Guerreiro"/>.
In order to restore basal amylin levels in mice, researchers have performed PEGylation, the addition of poly ethylene glycol, to amylin within residues 1-11 of the peptide, most likely at the two amine groups of K1<ref name="Guerreiro">PMID: 23818080</ref>. Administration of the modified amylin in mice showed evidence of reduced glycemia and prolonged action compared to endogenous amylin <ref name="Guerreiro"/>.
 +
 +
[[Image:align.png|300px|left|thumb|Figure 2:Amylin (green) aligned with Pramlintide (red)]]
 +
[[Image:pram sequence align.png|300px|right|thumb|Figure 3:Pramlintide Sequence alignment with varying forms of amylin. Atoms C2—C7 and K1 of the N-terminal region are conserved​. Y37 and T36 of the C-terminal region are also conserved.]]
 +
== References ==
== References ==

Revision as of 14:25, 25 April 2024

AMYR

AMYR Bound to Amylin

Drag the structure with the mouse to rotate


Student Contributors

Andrew Helmerich, Mathias Vander Eide, Ben Whiteside

Personal tools