Cullin-associated NEDD8-disassociated protein

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== Structural highlights ==
== Structural highlights ==
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This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
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The 3D structure of the complex between CAND1, cullin1 and RBX as well as other 3D structures of the SCF ubiquitin E3 ligases provide a mechanism of multiprotein complex assembly that averts supply chain problems and rapidly establishes protein degradation pathways needed for cellular regulation<ref>PMID:37028429</ref>.
== 3D structures of cullin-associated NEDD8-disassociated protein 1 ==
== 3D structures of cullin-associated NEDD8-disassociated protein 1 ==

Revision as of 08:52, 28 April 2024

Human CAND1 (yellow) complex with cullin1 (pink) and RBX1 (blue) (PDB id 7z8r)

Drag the structure with the mouse to rotate

References

  1. ↑ Pierce NW, Lee JE, Liu X, Sweredoski MJ, Graham RL, Larimore EA, Rome M, Zheng N, Clurman BE, Hess S, Shan SO, Deshaies RJ. Cand1 promotes assembly of new SCF complexes through dynamic exchange of F box proteins. Cell. 2013 Mar 28;153(1):206-15. PMID:23453757 doi:10.1016/j.cell.2013.02.024
  2. ↑ Cheng W, Yin S, Tu Y, Mei H, Wang Y, Yang Y. SlCAND1, encoding cullin-associated Nedd8-dissociated protein 1, regulates plant height, flowering time, seed germination, and root architecture in tomato. Plant Mol Biol. 2020 Mar;102(4-5):537-551. PMID:31916084 doi:10.1007/s11103-020-00963-7
  3. ↑ Li X, Zhang Y, Zhao Y, Zhou Y, Han Q, Yang Y, Zhang L, Shi L, Jin X, Zhang R, Gao H, Xue G, Li D, Zhang ZR, Lu Y, Yang B, Pan Z. Cullin-associated and neddylation-dissociated 1 protein (CAND1) governs cardiac hypertrophy and heart failure partially through regulating calcineurin degradation. Pharmacol Res. 2022 Aug;182:106284. PMID:35661710 doi:10.1016/j.phrs.2022.106284
  4. ↑ Huang X, Liu X, Li X, Zhang Y, Gao J, Yang Y, Jiang Y, Gao H, Sun C, Xuan L, Zhao L, Song J, Bao H, Zhou Z, Li S, Zhang X, Lu Y, Zhong X, Yang B, Pan Z. Cullin-associated and neddylation-dissociated protein 1 (CAND1) alleviates NAFLD by reducing ubiquitinated degradation of ACAA2. Nat Commun. 2023 Aug 1;14(1):4620. PMID:37528093 doi:10.1038/s41467-023-40327-5
  5. ↑ Baek K, Scott DC, Henneberg LT, King MT, Mann M, Schulman BA. Systemwide disassembly and assembly of SCF ubiquitin ligase complexes. Cell. 2023 Mar 31:S0092-8674(23)00213-1. PMID:37028429 doi:10.1016/j.cell.2023.02.035

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Michal Harel

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