Basigin

Function

Basigin or CD147 or EMMORIN is a transmembranal glycoprotein which is a receptor for a variety of proteins and is expressed by tumor cells^[1]. Basigin has several isoforms and contains immunoglobulin-like domains (Ig-like). Alternative splicing of basigin results in 4 different isoforms. Basigin-2 is the most predominant form and contains 2 Ig-like domains. Basigin-1 contains 3 Ig-like domains, basigin-3 contains 1 Ig-like domain^[2].

Disease

Relevance

Basigin is involved in regulation of glycolysis and thus in development of malignant tumors and T-cell-mediated immunological disorders^[3]. Hence, basigin has been termed a cancer-associated biomarker and serves as a target for cancer therapy.

Structural highlights

This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.