1rqf

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[[Image:1rqf.gif|left|200px]]
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{{STRUCTURE_1rqf| PDB=1rqf | SCENE= }}
{{STRUCTURE_1rqf| PDB=1rqf | SCENE= }}
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'''Structure of CK2 beta subunit crystallized in the presence of a p21WAF1 peptide'''
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===Structure of CK2 beta subunit crystallized in the presence of a p21WAF1 peptide===
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==Overview==
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A truncated form of the regulatory subunit of the protein kinase CK2beta (residues 1-178) has been crystallized in the presence of a fragment of the cyclin-dependent kinase inhibitor p21WAF1 (residues 46-65) and the structure solved at 2.9 A resolution by molecular replacement. The core of the CK2beta dimer shows a high structural similarity with that identified in previous structural analyses of the dimer and the holoenzyme. However, the electron density corresponding to the substrate-binding acidic loop (residues 55-64) indicates two conformations that differ from that of the holoenzyme structure [Niefind et al. (2001), EMBO J. 20, 5320-5331]. Difference electron density near the dimerization region in each of the eight protomers in the asymmetric unit is attributed to between one and eight amino-acid residues of a complexed fragment of p21WAF1. This binding site corresponds to the solvent-accessible part of the conserved zinc-finger motif.
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The line below this paragraph, {{ABSTRACT_PUBMED_15388915}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15388915 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15388915}}
==About this Structure==
==About this Structure==
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[[Category: Ser/thr protein kinase]]
[[Category: Ser/thr protein kinase]]
[[Category: Zn finger]]
[[Category: Zn finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:47:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:34:39 2008''

Revision as of 10:34, 27 July 2008

Image:1rqf.png

Template:STRUCTURE 1rqf

Structure of CK2 beta subunit crystallized in the presence of a p21WAF1 peptide

Template:ABSTRACT PUBMED 15388915

About this Structure

1RQF is a Single protein structure of sequence from Xenopus laevis. Full crystallographic information is available from OCA.

Reference

Structure of the regulatory subunit of CK2 in the presence of a p21WAF1 peptide demonstrates flexibility of the acidic loop., Bertrand L, Sayed MF, Pei XY, Parisini E, Dhanaraj V, Bolanos-Garcia VM, Allende JE, Blundell TL, Acta Crystallogr D Biol Crystallogr. 2004 Oct;60(Pt 10):1698-704. Epub, 2004 Sep 23. PMID:15388915

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