This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1rqy

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1rqy.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1rqy.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1rqy| PDB=1rqy | SCENE= }}
{{STRUCTURE_1rqy| PDB=1rqy | SCENE= }}
-
'''9-amino-[N-(2-dimethylamino)proply]-acridine-4-carboxamide bound to d(CGTACG)2'''
+
===9-amino-[N-(2-dimethylamino)proply]-acridine-4-carboxamide bound to d(CGTACG)2===
-
==Overview==
+
<!--
-
The structure of the complex formed between 9-amino-[N-(2-dimethylamino)propyl]acridine-4-carboxamide and d(CGTACG)(2) has been refined to a resolution of 1.55 A. The complex crystallized in space group C222. An asymmetric unit comprises two strands of DNA, one disordered drug molecule, two cobalt(II) ions, two magnesium ions and 32 water molecules. The DNA helices stack in continuous columns, with their four central base pairs adopting a B-like motif. The terminal G.C base pairs engage in different interactions. At one end of the duplex there is a CpG dinucleotide overlap modified by ligand intercalation and terminal cytosine exchange between symmetry-related duplexes. An intercalation complex is formed involving four DNA duplexes, four disordered ligand molecules and two pairs of base tetrads. The other end of the DNA is frayed, with the terminal guanine lying in the minor groove of the next duplex in the column. The structure is stabilized by guanine N7-cobalt(II) coordination. The structure is compared with previously published isomorphous structures of d(CGTACG)(2) complexed with intercalators in the presence of cobalt and it is concluded that the formation of this crystal form is primarily determined by DNA-DNA interactions and packing forces, rather than by special interactions between the ligand and the DNA. Given the nature of the ligands found in these complexes, the relevance of the quadruplex structure to the biological activity of those agents, known to be topoisomerase poisons, is questioned.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15103127}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15103127 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15103127}}
==About this Structure==
==About this Structure==
Line 29: Line 33:
[[Category: Quadruplex]]
[[Category: Quadruplex]]
[[Category: Unusual intercalation]]
[[Category: Unusual intercalation]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:48:40 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:47:58 2008''

Revision as of 06:48, 29 July 2008

Image:1rqy.png

Template:STRUCTURE 1rqy

9-amino-[N-(2-dimethylamino)proply]-acridine-4-carboxamide bound to d(CGTACG)2

Template:ABSTRACT PUBMED 15103127

About this Structure

Full crystallographic information is available from OCA.

Reference

Structure of 9-amino-[N-(2-dimethylamino)propyl]acridine-4-carboxamide bound to d(CGTACG)(2): a comparison of structures of d(CGTACG)(2) complexed with intercalatorsin the presence of cobalt., Adams A, Guss JM, Denny WA, Wakelin LP, Acta Crystallogr D Biol Crystallogr. 2004 May;60(Pt 5):823-8. Epub 2004, Apr 21. PMID:15103127

Page seeded by OCA on Tue Jul 29 09:47:58 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1rqy"
Personal tools