9eo1

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Current revision (06:25, 29 January 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9eo1 is ON HOLD until Paper Publication
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==Cryo_EM structure of human FAN1 in complex with 5' flap DNA substrate==
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<StructureSection load='9eo1' size='340' side='right'caption='[[9eo1]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9eo1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9EO1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9EO1 FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9eo1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9eo1 OCA], [https://pdbe.org/9eo1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9eo1 RCSB], [https://www.ebi.ac.uk/pdbsum/9eo1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9eo1 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/FAN1_HUMAN FAN1_HUMAN] Karyomegalic interstitial nephritis. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/FAN1_HUMAN FAN1_HUMAN] Nuclease required for maintenance of chromosomal stability. Plays a key role in DNA repair of DNA interstrand cross-links (ICL) by being recruited to sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, possibly in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Has both endonuclease activity toward 5'-flaps and 5'-exonuclease activity: may act in concert with the 3'-flap-specific enzymes to unhook the ICL by cleaving the lagging-strand template.<ref>PMID:20603015</ref> <ref>PMID:20603016</ref> <ref>PMID:20603073</ref> <ref>PMID:20671156</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Jeyasankar G]]
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[[Category: Salerno-Kochan A]]
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[[Category: Thomsen M]]

Current revision

Cryo_EM structure of human FAN1 in complex with 5' flap DNA substrate

PDB ID 9eo1

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OCA

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