This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1rrp

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1rrp.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1rrp.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1rrp| PDB=1rrp | SCENE= }}
{{STRUCTURE_1rrp| PDB=1rrp | SCENE= }}
-
'''STRUCTURE OF THE RAN-GPPNHP-RANBD1 COMPLEX'''
+
===STRUCTURE OF THE RAN-GPPNHP-RANBD1 COMPLEX===
-
==Overview==
+
<!--
-
The protein Ran is a small GTP-binding protein that binds to two types of effector inside the cell: Ran-binding proteins, which have a role in terminating export processes from the nucleus to the cytoplasm, and importin-beta-like molecules that bind cargo proteins during nuclear transport. The Ran-binding domain is a conserved sequence motif found in several proteins that participate in these transport processes. The Ran-binding protein RanBP2 contains four of these domains and constitutes a large part of the cytoplasmic fibrils that extend from the nuclear-pore complex. The structure of Ran bound to a non-hydrolysable GTP analogue (Ran x GppNHp) in complex with the first Ran-binding domain (RanBD1) of human RanBP2 reveals not only that RanBD1 has a pleckstrin-homology domain fold, but also that the switch-I region of Ran x GppNHp resembles the canonical Ras GppNHp structure and that the carboxy terminus of Ran is wrapped around RanBD1, contacting a basic patch on RanBD1 through its acidic end. This molecular 'embrace' enables RanBDs to sequester the Ran carboxy terminus, triggering the dissociation of Ran x GTP from importin-beta-related transport factors and facilitating GTP hydrolysis by the GTPase-activating protein ranGAP. Such a mechanism represents a new type of switch mechanism and regulatory protein-protein interaction for a Ras-related protein.
+
The line below this paragraph, {{ABSTRACT_PUBMED_10078529}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 10078529 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_10078529}}
==About this Structure==
==About this Structure==
Line 29: Line 33:
[[Category: Nuclear transport]]
[[Category: Nuclear transport]]
[[Category: Small gtpase]]
[[Category: Small gtpase]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:50:01 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:49:57 2008''

Revision as of 01:49, 28 July 2008

Image:1rrp.png

Template:STRUCTURE 1rrp

STRUCTURE OF THE RAN-GPPNHP-RANBD1 COMPLEX

Template:ABSTRACT PUBMED 10078529

About this Structure

1RRP is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: implications for nuclear transport., Vetter IR, Nowak C, Nishimoto T, Kuhlmann J, Wittinghofer A, Nature. 1999 Mar 4;398(6722):39-46. PMID:10078529

Page seeded by OCA on Mon Jul 28 04:49:57 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1rrp"
Personal tools