1rrq

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1rrq.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1rrq.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1rrq| PDB=1rrq | SCENE= }}
{{STRUCTURE_1rrq| PDB=1rrq | SCENE= }}
-
'''MutY adenine glycosylase in complex with DNA containing an A:oxoG pair'''
+
===MutY adenine glycosylase in complex with DNA containing an A:oxoG pair===
-
==Overview==
+
<!--
-
The genomes of aerobic organisms suffer chronic oxidation of guanine to the genotoxic product 8-oxoguanine (oxoG). Replicative DNA polymerases misread oxoG residues and insert adenine instead of cytosine opposite the oxidized base. Both bases in the resulting A*oxoG mispair are mutagenic lesions, and both must undergo base-specific replacement to restore the original C*G pair. Doing so represents a formidable challenge to the DNA repair machinery, because adenine makes up roughly 25% of the bases in most genomes. The evolutionarily conserved enzyme adenine DNA glycosylase (called MutY in bacteria and hMYH in humans) initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. A central issue concerning MutY function is the mechanism by which A*oxoG mispairs are targeted among the vast excess of A*T pairs. Here we report the use of disulphide crosslinking to obtain high-resolution crystal structures of MutY-DNA lesion-recognition complexes. These structures reveal the basis for recognizing both lesions in the A*oxoG pair and for catalysing removal of the adenine base.
+
The line below this paragraph, {{ABSTRACT_PUBMED_14961129}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 14961129 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_14961129}}
==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: Dna repair]]
[[Category: Dna repair]]
[[Category: Protein-dna complex]]
[[Category: Protein-dna complex]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:50:01 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:56:23 2008''

Revision as of 05:56, 28 July 2008

Image:1rrq.png

Template:STRUCTURE 1rrq

MutY adenine glycosylase in complex with DNA containing an A:oxoG pair

Template:ABSTRACT PUBMED 14961129

About this Structure

1RRQ is a Single protein structure of sequence from Geobacillus stearothermophilus. Full crystallographic information is available from OCA.

Reference

Structural basis for removal of adenine mispaired with 8-oxoguanine by MutY adenine DNA glycosylase., Fromme JC, Banerjee A, Huang SJ, Verdine GL, Nature. 2004 Feb 12;427(6975):652-6. PMID:14961129

Page seeded by OCA on Mon Jul 28 08:56:23 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1rrq"
Personal tools