1rrs

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{{STRUCTURE_1rrs| PDB=1rrs | SCENE= }}
{{STRUCTURE_1rrs| PDB=1rrs | SCENE= }}
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'''MutY adenine glycosylase in complex with DNA containing an abasic site'''
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===MutY adenine glycosylase in complex with DNA containing an abasic site===
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==Overview==
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The genomes of aerobic organisms suffer chronic oxidation of guanine to the genotoxic product 8-oxoguanine (oxoG). Replicative DNA polymerases misread oxoG residues and insert adenine instead of cytosine opposite the oxidized base. Both bases in the resulting A*oxoG mispair are mutagenic lesions, and both must undergo base-specific replacement to restore the original C*G pair. Doing so represents a formidable challenge to the DNA repair machinery, because adenine makes up roughly 25% of the bases in most genomes. The evolutionarily conserved enzyme adenine DNA glycosylase (called MutY in bacteria and hMYH in humans) initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. A central issue concerning MutY function is the mechanism by which A*oxoG mispairs are targeted among the vast excess of A*T pairs. Here we report the use of disulphide crosslinking to obtain high-resolution crystal structures of MutY-DNA lesion-recognition complexes. These structures reveal the basis for recognizing both lesions in the A*oxoG pair and for catalysing removal of the adenine base.
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The line below this paragraph, {{ABSTRACT_PUBMED_14961129}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14961129 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14961129}}
==About this Structure==
==About this Structure==
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[[Category: Dna repair]]
[[Category: Dna repair]]
[[Category: Protein-dna complex]]
[[Category: Protein-dna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:50:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:33:06 2008''

Revision as of 10:33, 27 July 2008

Image:1rrs.png

Template:STRUCTURE 1rrs

MutY adenine glycosylase in complex with DNA containing an abasic site

Template:ABSTRACT PUBMED 14961129

About this Structure

1RRS is a Single protein structure of sequence from Geobacillus stearothermophilus. Full crystallographic information is available from OCA.

Reference

Structural basis for removal of adenine mispaired with 8-oxoguanine by MutY adenine DNA glycosylase., Fromme JC, Banerjee A, Huang SJ, Verdine GL, Nature. 2004 Feb 12;427(6975):652-6. PMID:14961129

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