1rsm

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{{STRUCTURE_1rsm| PDB=1rsm | SCENE= }}
{{STRUCTURE_1rsm| PDB=1rsm | SCENE= }}
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'''THE 2-ANGSTROMS RESOLUTION STRUCTURE OF A THERMOSTABLE RIBONUCLEASE A CHEMICALLY CROSS-LINKED BETWEEN LYSINE RESIDUES 7 AND 41'''
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===THE 2-ANGSTROMS RESOLUTION STRUCTURE OF A THERMOSTABLE RIBONUCLEASE A CHEMICALLY CROSS-LINKED BETWEEN LYSINE RESIDUES 7 AND 41===
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==Overview==
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The crystal structure of Lys-7-(dinitrophenylene)-Lys-41-cross-linked ribonuclease A has been determined by molecular replacement and refined by restrained least-squares methods to an R factor of 0.18 at 2.0-A resolution. Diffraction intensity data were collected by using a conventional diffractometer and an x-ray area detector. Comparison of the thermostable cross-linked protein and the native enzyme shows them to be structurally similar, with a rms difference in backbone and side-chain atoms of 0.52 and 1.34 A, respectively. Native and modified proteins additionally show 35 common bound solvent sites and similar overall temperature factor behavior, despite localized differences resulting from cross-link introduction, altered crystal pH, or lattice interactions with neighboring molecules. These results are discussed in the context of proposals on the origins of thermostability in the cross-linked enzyme.
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The line below this paragraph, {{ABSTRACT_PUBMED_3936036}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 3936036 is the PubMed ID number.
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{{ABSTRACT_PUBMED_3936036}}
==About this Structure==
==About this Structure==
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[[Category: Sheriff, S.]]
[[Category: Sheriff, S.]]
[[Category: Weber, P C.]]
[[Category: Weber, P C.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:51:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:50:48 2008''

Revision as of 08:50, 29 July 2008

Image:1rsm.png

Template:STRUCTURE 1rsm

THE 2-ANGSTROMS RESOLUTION STRUCTURE OF A THERMOSTABLE RIBONUCLEASE A CHEMICALLY CROSS-LINKED BETWEEN LYSINE RESIDUES 7 AND 41

Template:ABSTRACT PUBMED 3936036

About this Structure

1RSM is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

The 2-A resolution structure of a thermostable ribonuclease A chemically cross-linked between lysine residues 7 and 41., Weber PC, Sheriff S, Ohlendorf DH, Finzel BC, Salemme FR, Proc Natl Acad Sci U S A. 1985 Dec;82(24):8473-7. PMID:3936036

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