1rso

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[[Image:1rso.gif|left|200px]]
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{{STRUCTURE_1rso| PDB=1rso | SCENE= }}
{{STRUCTURE_1rso| PDB=1rso | SCENE= }}
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'''Hetero-tetrameric L27 (Lin-2, Lin-7) domain complexes as organization platforms of supra-molecular assemblies'''
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===Hetero-tetrameric L27 (Lin-2, Lin-7) domain complexes as organization platforms of supra-molecular assemblies===
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==Overview==
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L27 domain, initially identified in the Caenorhabditis elegans Lin-2 and Lin-7 proteins, is a protein interaction module that exists in a large family of scaffold proteins. The domain can function as an organization center of large protein assemblies required for establishment and maintenance of cell polarity. We have solved the high-resolution NMR structure of a tetrameric complex of L27 domains containing two SAP97-mLin-2 L27 domain heterodimers. Each L27 domain contains three a-helices. The first two helices of each domain are packed together to form a four-helical bundle in the heterodimer. The third helix of each L27 domain forms another four-helical bundle that assembles the two heterodimers into a tetramer. The structure of the complex provides a mechanistic explanation for L27 domain-mediated polymerization of scaffold proteins, a process that is crucial for the assembly of supramolecular complexes in asymmetric cells.
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{{ABSTRACT_PUBMED_15048107}}
==About this Structure==
==About this Structure==
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1RSO is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RSO OCA].
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1RSO is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RSO OCA].
==Reference==
==Reference==
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[[Category: Protein assembly]]
[[Category: Protein assembly]]
[[Category: Scaffold protein]]
[[Category: Scaffold protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:51:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:51:49 2008''

Revision as of 21:51, 28 July 2008

Image:1rso.png

Template:STRUCTURE 1rso

Hetero-tetrameric L27 (Lin-2, Lin-7) domain complexes as organization platforms of supra-molecular assemblies

Template:ABSTRACT PUBMED 15048107

About this Structure

1RSO is a Protein complex structure of sequences from Rattus norvegicus. Full experimental information is available from OCA.

Reference

The tetrameric L27 domain complex as an organization platform for supramolecular assemblies., Feng W, Long JF, Fan JS, Suetake T, Zhang M, Nat Struct Mol Biol. 2004 May;11(5):475-80. Epub 2004 Mar 28. PMID:15048107

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