1rt8

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1rt8.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1rt8.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1rt8| PDB=1rt8 | SCENE= }}
{{STRUCTURE_1rt8| PDB=1rt8 | SCENE= }}
-
'''CRYSTAL STRUCTURE OF THE ACTIN-CROSSLINKING CORE OF SCHIZOSACCHAROMYCES POMBE FIMBRIN'''
+
===CRYSTAL STRUCTURE OF THE ACTIN-CROSSLINKING CORE OF SCHIZOSACCHAROMYCES POMBE FIMBRIN===
-
==Overview==
+
<!--
-
Filamentous actin is organized into bundles and orthogonal networks by the fimbrin/alpha-actinin superfamily of F-actin crosslinking proteins. The crystal structure of the Arabidopsis thaliana and Schizosaccharomyces pombe fimbrin cores provides the first description of a functional F-actin crosslinking protein and highlights the compact and distinctly asymmetric organization of the fimbrin molecule, in which the two actin binding domains present distinct surfaces to solvent. The mapping of functionally important residues onto the structure affords new insights into the binding process and provides additional constraints which must be accommodated by models for F-actin binding and crosslinking. Most strikingly, this work provides unique insight into the mechanistic features of conditional-lethal mutants and their extragenic suppressors, which highlight conformational and dynamic properties required for fimbrin function. These results underscore the power of jointly considering structural and genetic suppressor data for obtaining unexpected and biologically relevant mechanistic information.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15274920}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15274920 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15274920}}
==About this Structure==
==About this Structure==
Line 32: Line 36:
[[Category: Actin-crosslinking]]
[[Category: Actin-crosslinking]]
[[Category: Calponin homology]]
[[Category: Calponin homology]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:52:42 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:18:05 2008''

Revision as of 13:18, 28 July 2008

Image:1rt8.png

Template:STRUCTURE 1rt8

CRYSTAL STRUCTURE OF THE ACTIN-CROSSLINKING CORE OF SCHIZOSACCHAROMYCES POMBE FIMBRIN

Template:ABSTRACT PUBMED 15274920

About this Structure

1RT8 is a Single protein structure of sequence from Schizosaccharomyces pombe. Full crystallographic information is available from OCA.

Reference

Structure of the actin crosslinking core of fimbrin., Klein MG, Shi W, Ramagopal U, Tseng Y, Wirtz D, Kovar DR, Staiger CJ, Almo SC, Structure. 2004 Jun;12(6):999-1013. PMID:15274920

Page seeded by OCA on Mon Jul 28 16:18:05 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1rt8"
Personal tools