1rtd

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{{Seed}}
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{{STRUCTURE_1rtd| PDB=1rtd | SCENE= }}
{{STRUCTURE_1rtd| PDB=1rtd | SCENE= }}
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'''STRUCTURE OF A CATALYTIC COMPLEX OF HIV-1 REVERSE TRANSCRIPTASE: IMPLICATIONS FOR NUCLEOSIDE ANALOG DRUG RESISTANCE'''
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===STRUCTURE OF A CATALYTIC COMPLEX OF HIV-1 REVERSE TRANSCRIPTASE: IMPLICATIONS FOR NUCLEOSIDE ANALOG DRUG RESISTANCE===
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==Overview==
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A combinatorial disulfide cross-linking strategy was used to prepare a stalled complex of human immunodeficiency virus-type 1 (HIV-1) reverse transcriptase with a DNA template:primer and a deoxynucleoside triphosphate (dNTP), and the crystal structure of the complex was determined at a resolution of 3.2 angstroms. The presence of a dideoxynucleotide at the 3'-primer terminus allows capture of a state in which the substrates are poised for attack on the dNTP. Conformational changes that accompany formation of the catalytic complex produce distinct clusters of the residues that are altered in viruses resistant to nucleoside analog drugs. The positioning of these residues in the neighborhood of the dNTP helps to resolve some long-standing puzzles about the molecular basis of resistance. The resistance mutations are likely to influence binding or reactivity of the inhibitors, relative to normal dNTPs, and the clustering of the mutations correlates with the chemical structure of the drug.
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(as it appears on PubMed at http://www.pubmed.gov), where 9831551 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9831551}}
==About this Structure==
==About this Structure==
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[[Category: Dna]]
[[Category: Dna]]
[[Category: Protein/dna]]
[[Category: Protein/dna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:52:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:08:54 2008''

Revision as of 05:08, 28 July 2008

Image:1rtd.png

Template:STRUCTURE 1rtd

STRUCTURE OF A CATALYTIC COMPLEX OF HIV-1 REVERSE TRANSCRIPTASE: IMPLICATIONS FOR NUCLEOSIDE ANALOG DRUG RESISTANCE

Template:ABSTRACT PUBMED 9831551

About this Structure

1RTD is a Protein complex structure of sequences from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance., Huang H, Chopra R, Verdine GL, Harrison SC, Science. 1998 Nov 27;282(5394):1669-75. PMID:9831551

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