1rtx

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{{STRUCTURE_1rtx| PDB=1rtx | SCENE= }}
{{STRUCTURE_1rtx| PDB=1rtx | SCENE= }}
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'''Crystal Structure of Synechocystis Hemoglobin with a Covalent Heme Linkage'''
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===Crystal Structure of Synechocystis Hemoglobin with a Covalent Heme Linkage===
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==Overview==
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The x-ray crystal structure of Synechocystis hemoglobin has been solved to a resolution of 1.8 A. The conformation of this structure is surprisingly different from that of the previously reported solution structure, probably due in part to a covalent linkage between the heme 2-vinyl and His117 that is present in the crystal structure but not in the structure solved by NMR. Synechocystis hemoglobin is a hexacoordinate hemoglobin in which the heme iron is coordinated by both the proximal and distal histidines. It is also a member of the "truncated hemoglobin" family that is much shorter in primary structure than vertebrate and plant hemoglobins. In contrast to other truncated hemoglobins, the crystal structure of Synechocystis hemoglobin displays no "ligand tunnel" and shows that several important amino acid side chains extrude into the solvent instead of residing inside the heme pocket. The stereochemistry of hexacoordination is compared with other hexacoordinate hemoglobins and cytochromes in an effort to illuminate factors contributing to ligand affinity in hexacoordinate hemoglobins.
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The line below this paragraph, {{ABSTRACT_PUBMED_14736872}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14736872 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14736872}}
==About this Structure==
==About this Structure==
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[[Category: Synechocystis hemoglobin]]
[[Category: Synechocystis hemoglobin]]
[[Category: Truncated]]
[[Category: Truncated]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:54:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:55:22 2008''

Revision as of 17:55, 27 July 2008

Image:1rtx.png

Template:STRUCTURE 1rtx

Crystal Structure of Synechocystis Hemoglobin with a Covalent Heme Linkage

Template:ABSTRACT PUBMED 14736872

About this Structure

1RTX is a Single protein structure of sequence from Synechocystis sp.. Full crystallographic information is available from OCA.

Reference

The crystal structure of Synechocystis hemoglobin with a covalent heme linkage., Hoy JA, Kundu S, Trent JT 3rd, Ramaswamy S, Hargrove MS, J Biol Chem. 2004 Apr 16;279(16):16535-42. Epub 2004 Jan 21. PMID:14736872

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