6z31
From Proteopedia
(Difference between revisions)
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<StructureSection load='6z31' size='340' side='right'caption='[[6z31]], [[Resolution|resolution]] 2.56Å' scene=''> | <StructureSection load='6z31' size='340' side='right'caption='[[6z31]], [[Resolution|resolution]] 2.56Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'> | + | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z31 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Z31 FirstGlance]. <br> |
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.56Å</td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.56Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6z31 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z31 OCA], [https://pdbe.org/6z31 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6z31 RCSB], [https://www.ebi.ac.uk/pdbsum/6z31 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6z31 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6z31 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z31 OCA], [https://pdbe.org/6z31 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6z31 RCSB], [https://www.ebi.ac.uk/pdbsum/6z31 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6z31 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Function == | ||
| - | [https://www.uniprot.org/uniprot/MPRI_HUMAN MPRI_HUMAN] Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.<ref>PMID:10900005</ref> | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Bochel AJ]] | [[Category: Bochel AJ]] | ||
[[Category: Crump MP]] | [[Category: Crump MP]] | ||
[[Category: Williams C]] | [[Category: Williams C]] | ||
Current revision
Human cation-independent mannose 6-phosphate/ IGF2 receptor domain 8
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