7nxl
From Proteopedia
(Difference between revisions)
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<StructureSection load='7nxl' size='340' side='right'caption='[[7nxl]], [[Resolution|resolution]] 1.80Å' scene=''> | <StructureSection load='7nxl' size='340' side='right'caption='[[7nxl]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'> | + | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NXL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NXL FirstGlance]. <br> |
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UUK:tert-butyl+(1-((4-(dibenzylamino)-4-oxobutyl)amino)-4-methyl-1-oxopentan-2-yl)carbamate'>UUK</scene></td></tr> | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UUK:tert-butyl+(1-((4-(dibenzylamino)-4-oxobutyl)amino)-4-methyl-1-oxopentan-2-yl)carbamate'>UUK</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nxl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nxl OCA], [https://pdbe.org/7nxl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nxl RCSB], [https://www.ebi.ac.uk/pdbsum/7nxl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nxl ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nxl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nxl OCA], [https://pdbe.org/7nxl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nxl RCSB], [https://www.ebi.ac.uk/pdbsum/7nxl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nxl ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Disease == | ||
| - | [https://www.uniprot.org/uniprot/CATK_HUMAN CATK_HUMAN] Defects in CTSK are the cause of pycnodysostosis (PKND) [MIM:[https://omim.org/entry/265800 265800]. PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature.<ref>PMID:8703060</ref> <ref>PMID:9529353</ref> <ref>PMID:10491211</ref> <ref>PMID:10878663</ref> | ||
| - | == Function == | ||
| - | [https://www.uniprot.org/uniprot/CATK_HUMAN CATK_HUMAN] Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. | ||
==See Also== | ==See Also== | ||
*[[Cathepsin 3D structures|Cathepsin 3D structures]] | *[[Cathepsin 3D structures|Cathepsin 3D structures]] | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Benysek J]] | [[Category: Benysek J]] | ||
Current revision
Structure of human cathepsin K in complex with the acrylamide inhibitor Gu3110
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Categories: Large Structures | Benysek J | Busa M | Gutschow M | Lemke C | Mares M
