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1rw3

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[[Image:1rw3.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1rw3| PDB=1rw3 | SCENE= }}
{{STRUCTURE_1rw3| PDB=1rw3 | SCENE= }}
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'''The crystal structure of the monomeric reverse transcriptase from Moloney murine leukemia virus'''
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===The crystal structure of the monomeric reverse transcriptase from Moloney murine leukemia virus===
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==Overview==
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Reverse transcriptases (RTs) are multidomain enzymes of variable architecture that couple both RNA- and DNA-directed DNA polymerase activities with an RNase H activity specific for an RNA:DNA hybrid in order to replicate the single-stranded RNA genome of the retrovirus. Previous structural work has been reported for the heterodimeric HIV-1 and HIV-2 RTs. We now report the first crystal structure of the full-length Moloney murine leukemia virus (MMLV) RT at 3.0 A resolution. The structure reveals a clamp-shaped molecule resulting from the relative positions of the thumb, connection, and RNase H domains that is strikingly different from the HIV-1 RT and provides the first example of a monomeric reverse transcriptase. A comparative analysis with related DNA polymerases suggests a unique trajectory for the template-primer exiting the polymerase active site and provides insights regarding processive DNA synthesis by MMLV RT.
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(as it appears on PubMed at http://www.pubmed.gov), where 15130474 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15130474}}
==About this Structure==
==About this Structure==
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[[Category: Reverse transcriptase]]
[[Category: Reverse transcriptase]]
[[Category: Rna and dna dependent dna polymerase]]
[[Category: Rna and dna dependent dna polymerase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:58:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:41:29 2008''

Revision as of 02:41, 29 July 2008

Image:1rw3.png

Template:STRUCTURE 1rw3

The crystal structure of the monomeric reverse transcriptase from Moloney murine leukemia virus

Template:ABSTRACT PUBMED 15130474

About this Structure

1RW3 is a Single protein structure of sequence from Moloney murine leukemia virus. Full crystallographic information is available from OCA.

Reference

The crystal structure of the monomeric reverse transcriptase from Moloney murine leukemia virus., Das D, Georgiadis MM, Structure. 2004 May;12(5):819-29. PMID:15130474

Page seeded by OCA on Tue Jul 29 05:41:29 2008

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