This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1rw6

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1rw6.jpg|left|200px]]
+
[[Image:1rw6.png|left|200px]]
<!--
<!--
Line 12: Line 12:
-
==Overview==
+
{{ABSTRACT_15304215}}
-
Amyloid beta-peptide, which forms neuronal and vascular amyloid deposits in Alzheimer's disease, is derived from an integral membrane protein precursor. The biological function of the precursor is currently unclear. Here we describe the X-ray structure of E2, the largest of the three conserved domains of the precursor. The structure of E2 consists of two coiled-coil substructures connected through a continuous helix and bears an unexpected resemblance to the spectrin family of protein structures. E2 can reversibly dimerize in the solution, and the dimerization occurs along the longest dimension of the molecule in an antiparallel orientation, which enables the N-terminal substructure of one monomer to pack against the C-terminal substructure of a second monomer. Heparan sulfate proteoglycans, the putative ligand for the precursor present in extracellular matrix, bind to E2 at a conserved and positively charged site near the dimer interface.
+
==Disease==
==Disease==
Line 20: Line 19:
==About this Structure==
==About this Structure==
1RW6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1RW6 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb79_1.html Amyloid-beta Precursor Protein]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RW6 OCA].
1RW6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1RW6 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb79_1.html Amyloid-beta Precursor Protein]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RW6 OCA].
- 
-
==Reference==
 
-
The X-ray structure of an antiparallel dimer of the human amyloid precursor protein E2 domain., Wang Y, Ha Y, Mol Cell. 2004 Aug 13;15(3):343-53. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15304215 15304215]
 
[[Category: Amyloid-beta Precursor Protein]]
[[Category: Amyloid-beta Precursor Protein]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
Line 30: Line 26:
[[Category: Coiled-coil]]
[[Category: Coiled-coil]]
[[Category: Dimer]]
[[Category: Dimer]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:58:42 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:56:07 2008''

Revision as of 14:56, 26 June 2008

Image:1rw6.png

Template:STRUCTURE 1rw6

human APP core domain


Template:ABSTRACT 15304215

Disease

Known disease associated with this structure: Alzheimer disease-1, APP-related OMIM:[104760], Amyloidosis, cerebroarterial, Dutch type OMIM:[104760], Amyloidosis, cerebroarterial, Iowa type OMIM:[104760]

About this Structure

1RW6 is a Single protein structure of sequence from Homo sapiens. The following page contains interesting information on the relation of 1RW6 with [Amyloid-beta Precursor Protein]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:56:07 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1rw6"
Personal tools