1ulb
From Proteopedia
(New page: 200px<br /> <applet load="1ulb" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ulb, resolution 2.75Å" /> '''APPLICATION OF CRYS...) |
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caption="1ulb, resolution 2.75Å" /> | caption="1ulb, resolution 2.75Å" /> | ||
'''APPLICATION OF CRYSTALLOGRAPHIC AND MODELING METHODS IN THE DESIGN OF PURINE NUCLEOSIDE PHOSPHORYLASE INHIBITORS'''<br /> | '''APPLICATION OF CRYSTALLOGRAPHIC AND MODELING METHODS IN THE DESIGN OF PURINE NUCLEOSIDE PHOSPHORYLASE INHIBITORS'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1ULB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4 and GUN as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Purine-nucleoside_phosphorylase Purine-nucleoside phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.1 2.4.2.1] Full crystallographic information is available from [http:// | + | 1ULB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=GUN:'>GUN</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Purine-nucleoside_phosphorylase Purine-nucleoside phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.1 2.4.2.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ULB OCA]. |
==Reference== | ==Reference== | ||
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[[Category: pentosyltransferase]] | [[Category: pentosyltransferase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:03:05 2008'' |
Revision as of 15:03, 15 February 2008
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APPLICATION OF CRYSTALLOGRAPHIC AND MODELING METHODS IN THE DESIGN OF PURINE NUCLEOSIDE PHOSPHORYLASE INHIBITORS
Contents |
Overview
Competitive inhibitors of the salvage pathway enzyme purine-nucleoside, phosphorylase (purine-nucleoside:orthophosphate ribosyltransferase, EC, 2.4.2.1) have been designed by using the three-dimensional structure of, the enzyme as determined by x-ray crystallography. The process was an, iterative one that utilized interactive computer graphics, Monte, Carlo-based conformational searching, energy minimization, and x-ray, crystallography. The proposed compounds were synthesized and tested by an, in vitro assay. Among the compounds designed and synthesized are the most, potent competitive inhibitors of purine nucleoside phosphorylase thus far, reported.
Disease
Known diseases associated with this structure: Neutral lipid storage disease with myopathy OMIM:[609059], Nucleoside phosphorylase deficiency, immunodeficiency due to OMIM:[164050]
About this Structure
1ULB is a Single protein structure of sequence from Homo sapiens with and as ligands. Active as Purine-nucleoside phosphorylase, with EC number 2.4.2.1 Full crystallographic information is available from OCA.
Reference
Application of crystallographic and modeling methods in the design of purine nucleoside phosphorylase inhibitors., Ealick SE, Babu YS, Bugg CE, Erion MD, Guida WC, Montgomery JA, Secrist JA 3rd, Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11540-4. PMID:1763067
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