1ry2

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{{STRUCTURE_1ry2| PDB=1ry2 | SCENE= }}
{{STRUCTURE_1ry2| PDB=1ry2 | SCENE= }}
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'''Crystal structure of yeast acetyl-coenzyme A synthetase in complex with AMP'''
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===Crystal structure of yeast acetyl-coenzyme A synthetase in complex with AMP===
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==Overview==
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Acetyl-coenzyme A synthetase (ACS) belongs to the family of AMP-forming enzymes that also includes acyl-CoA synthetases, firefly luciferase, and nonribosomal peptide synthetases. ACS catalyzes the two-step activation of acetate to acetyl-CoA: formation of an acetyl-AMP intermediate from acetate and ATP and the transfer of the acetyl group to CoA. In mammals, the acetyl-CoA product is used for biosynthesis of long chain fatty acids as well as energy production. We have determined the crystal structure of yeast ACS in a binary complex with AMP at 2.3 A resolution. The structure contains a large, N-terminal domain and a small, C-terminal domain. AMP is bound at the interface between the two domains. This structure represents a new conformation for the ACS enzyme, which may be competent for catalyzing the first step of the reaction. A Lys residue that is critical for this step is located in the active site. A rotation of 140 degrees in the small domain is needed for the binding of CoA and the catalysis of the second step. In contrast to the monomeric bacterial enzyme, yeast ACS is a stable trimer.
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(as it appears on PubMed at http://www.pubmed.gov), where 14769018 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14769018}}
==About this Structure==
==About this Structure==
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[[Category: Amp forming]]
[[Category: Amp forming]]
[[Category: Related to firefly luciferase]]
[[Category: Related to firefly luciferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:02:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:04:25 2008''

Revision as of 13:04, 29 July 2008

Image:1ry2.png

Template:STRUCTURE 1ry2

Crystal structure of yeast acetyl-coenzyme A synthetase in complex with AMP

Template:ABSTRACT PUBMED 14769018

About this Structure

1RY2 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Crystal structure of yeast acetyl-coenzyme A synthetase in complex with AMP., Jogl G, Tong L, Biochemistry. 2004 Feb 17;43(6):1425-31. PMID:14769018

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