1ry4

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{{STRUCTURE_1ry4| PDB=1ry4 | SCENE= }}
{{STRUCTURE_1ry4| PDB=1ry4 | SCENE= }}
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'''NMR Structure of the CRIB-PDZ module of Par-6'''
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===NMR Structure of the CRIB-PDZ module of Par-6===
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==Overview==
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Regulation of protein interaction domains is required for cellular signaling dynamics. Here, we show that the PDZ protein interaction domain from the cell polarity protein Par-6 is regulated by the Rho GTPase Cdc42. Cdc42 binds to a CRIB domain adjacent to the PDZ domain, increasing the affinity of the Par-6 PDZ for its carboxy-terminal ligand by approximately 13-fold. Par-6 PDZ regulation is required for function as mutational disruption of Cdc42-Par-6 PDZ coupling leads to inactivation of Par-6 in polarized MDCK epithelial cells. Structural analysis reveals that the free PDZ domain has several deviations from the canonical PDZ conformation that account for its low ligand affinity. Regulation results from a Cdc42-induced conformational transition in the CRIB-PDZ module that causes the PDZ to assume a canonical, high-affinity PDZ conformation. The coupled CRIB and PDZ architecture of Par-6 reveals how simple binding domains can be combined to yield complex regulation.
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{{ABSTRACT_PUBMED_15023337}}
==About this Structure==
==About this Structure==
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1RY4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RY4 OCA].
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1RY4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RY4 OCA].
==Reference==
==Reference==
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[[Category: Pdz]]
[[Category: Pdz]]
[[Category: Polarity adaptor complex]]
[[Category: Polarity adaptor complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:03:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:57:57 2008''

Revision as of 02:58, 29 July 2008

Image:1ry4.png

Template:STRUCTURE 1ry4

NMR Structure of the CRIB-PDZ module of Par-6

Template:ABSTRACT PUBMED 15023337

About this Structure

1RY4 is a Single protein structure of sequence from Drosophila melanogaster. Full experimental information is available from OCA.

Reference

Cdc42 regulates the Par-6 PDZ domain through an allosteric CRIB-PDZ transition., Peterson FC, Penkert RR, Volkman BF, Prehoda KE, Mol Cell. 2004 Mar 12;13(5):665-76. PMID:15023337

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