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1ry9

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{{STRUCTURE_1ry9| PDB=1ry9 | SCENE= }}
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'''Spa15, a Type III Secretion Chaperone from Shigella flexneri'''
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===Spa15, a Type III Secretion Chaperone from Shigella flexneri===
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==Overview==
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Type III secretion (TTS) systems are used by many Gram-negative pathogens to inject virulence proteins into the cells of their hosts. Several of these virulence effectors require TTS chaperones that maintain them in a secretion-competent state. Whereas most chaperones bind only one effector, Spa15 from the human pathogen Shigella flexneri and homologous chaperones bind several seemingly unrelated effectors, and were proposed to form a special subgroup. Its 1.8 A crystal structure confirms this specific classification, showing that Spa15 has the same fold as other TTS effector chaperones, but forms a different dimer. The presence of hydrophobic sites on the Spa15 surface suggests that the different Spa15 effectors all possess similar structural elements that can bind these sites. Furthermore, the Spa15 structure reveals larger structural differences between class I chaperones than previously anticipated, which does not support the hypothesis that chaperone-effector complexes are structurally conserved and function as three-dimensional secretion signals.
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(as it appears on PubMed at http://www.pubmed.gov), where 15088068 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15088068}}
==About this Structure==
==About this Structure==
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[[Category: Perez, J.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:03:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:03:34 2008''

Revision as of 02:03, 29 July 2008

Image:1ry9.png

Template:STRUCTURE 1ry9

Spa15, a Type III Secretion Chaperone from Shigella flexneri

Template:ABSTRACT PUBMED 15088068

About this Structure

1RY9 is a Single protein structure of sequence from Shigella flexneri. Full crystallographic information is available from OCA.

Reference

Structure of Spa15, a type III secretion chaperone from Shigella flexneri with broad specificity., van Eerde A, Hamiaux C, Perez J, Parsot C, Dijkstra BW, EMBO Rep. 2004 May;5(5):477-83. Epub 2004 Apr 16. PMID:15088068

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