1ryh

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[[Image:1ryh.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1ryh| PDB=1ryh | SCENE= }}
{{STRUCTURE_1ryh| PDB=1ryh | SCENE= }}
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'''Alternative Splicing of Rac1 Generates Rac1b, a Self-activating GTPase'''
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===Alternative Splicing of Rac1 Generates Rac1b, a Self-activating GTPase===
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==Overview==
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Rac1b was recently identified in malignant colorectal tumors as an alternative splice variant of Rac1 containing a 19-amino acid insertion next to the switch II region. The structures of Rac1b in the GDP- and the GppNHp-bound forms, determined at a resolution of 1.75 A, reveal that the insertion induces an open switch I conformation and a highly mobile switch II. As a consequence, Rac1b has an accelerated GEF-independent GDP/GTP exchange and an impaired GTP hydrolysis, which is restored partially by GTPase-activating proteins. Interestingly, Rac1b is able to bind the GTPase-binding domain of PAK but not full-length PAK in a GTP-dependent manner, suggesting that the insertion does not completely abolish effector interaction. The presented study provides insights into the structural and biochemical mechanism of a self-activating GTPase.
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(as it appears on PubMed at http://www.pubmed.gov), where 14625275 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14625275}}
==About this Structure==
==About this Structure==
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[[Category: Fiegen, D.]]
[[Category: Fiegen, D.]]
[[Category: Gtp binding]]
[[Category: Gtp binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:03:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:00:18 2008''

Revision as of 09:00, 28 July 2008

Image:1ryh.png

Template:STRUCTURE 1ryh

Alternative Splicing of Rac1 Generates Rac1b, a Self-activating GTPase

Template:ABSTRACT PUBMED 14625275

About this Structure

1RYH is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Alternative splicing of Rac1 generates Rac1b, a self-activating GTPase., Fiegen D, Haeusler LC, Blumenstein L, Herbrand U, Dvorsky R, Vetter IR, Ahmadian MR, J Biol Chem. 2004 Feb 6;279(6):4743-9. Epub 2003 Nov 18. PMID:14625275

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