1rz8

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{{STRUCTURE_1rz8| PDB=1rz8 | SCENE= }}
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'''CRYSTAL STRUCTURE OF HUMAN ANTI-HIV-1 GP120-REACTIVE ANTIBODY 17B'''
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===CRYSTAL STRUCTURE OF HUMAN ANTI-HIV-1 GP120-REACTIVE ANTIBODY 17B===
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==Overview==
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The conserved surface of the HIV-1 gp120 envelope glycoprotein that binds to the HIV-1 coreceptor is protected from humoral recognition by multiple layers of camouflage. Here we present sequence and genomic analyses for 12 antibodies that pierce these defenses and determine the crystal structures of 5. The data reveal mechanisms and atomic-level details for three unusual immune features: posttranslational mimicry of coreceptor by tyrosine sulfation of antibody, an alternative molecular mechanism controlling such sulfation, and highly selective V(H)-gene usage. When confronted by extraordinary viral defenses, the immune system unveils novel adaptive capabilities, with tyrosine sulfation enhancing the vocabulary of antigen recognition.
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(as it appears on PubMed at http://www.pubmed.gov), where 14981267 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14981267}}
==About this Structure==
==About this Structure==
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[[Category: Tyrosine sulfation]]
[[Category: Tyrosine sulfation]]
[[Category: Vh-gene usage]]
[[Category: Vh-gene usage]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:05:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:50:21 2008''

Revision as of 09:50, 28 July 2008

Image:1rz8.png

Template:STRUCTURE 1rz8

CRYSTAL STRUCTURE OF HUMAN ANTI-HIV-1 GP120-REACTIVE ANTIBODY 17B

Template:ABSTRACT PUBMED 14981267

About this Structure

Full crystallographic information is available from OCA.

Reference

Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120., Huang CC, Venturi M, Majeed S, Moore MJ, Phogat S, Zhang MY, Dimitrov DS, Hendrickson WA, Robinson J, Sodroski J, Wyatt R, Choe H, Farzan M, Kwong PD, Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2706-11. Epub 2004 Feb 23. PMID:14981267

Page seeded by OCA on Mon Jul 28 12:50:21 2008

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