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1rzx

From Proteopedia

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{{STRUCTURE_1rzx| PDB=1rzx | SCENE= }}
{{STRUCTURE_1rzx| PDB=1rzx | SCENE= }}
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'''Crystal Structure of a Par-6 PDZ-peptide Complex'''
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===Crystal Structure of a Par-6 PDZ-peptide Complex===
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==Overview==
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Regulation of protein interaction domains is required for cellular signaling dynamics. Here, we show that the PDZ protein interaction domain from the cell polarity protein Par-6 is regulated by the Rho GTPase Cdc42. Cdc42 binds to a CRIB domain adjacent to the PDZ domain, increasing the affinity of the Par-6 PDZ for its carboxy-terminal ligand by approximately 13-fold. Par-6 PDZ regulation is required for function as mutational disruption of Cdc42-Par-6 PDZ coupling leads to inactivation of Par-6 in polarized MDCK epithelial cells. Structural analysis reveals that the free PDZ domain has several deviations from the canonical PDZ conformation that account for its low ligand affinity. Regulation results from a Cdc42-induced conformational transition in the CRIB-PDZ module that causes the PDZ to assume a canonical, high-affinity PDZ conformation. The coupled CRIB and PDZ architecture of Par-6 reveals how simple binding domains can be combined to yield complex regulation.
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The line below this paragraph, {{ABSTRACT_PUBMED_15023337}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15023337 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15023337}}
==About this Structure==
==About this Structure==
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[[Category: Volkman, F B.]]
[[Category: Volkman, F B.]]
[[Category: Cell cycle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:07:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:31:52 2008''

Revision as of 13:31, 27 July 2008

Image:1rzx.png

Template:STRUCTURE 1rzx

Crystal Structure of a Par-6 PDZ-peptide Complex

Template:ABSTRACT PUBMED 15023337

About this Structure

1RZX is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Cdc42 regulates the Par-6 PDZ domain through an allosteric CRIB-PDZ transition., Peterson FC, Penkert RR, Volkman BF, Prehoda KE, Mol Cell. 2004 Mar 12;13(5):665-76. PMID:15023337

Page seeded by OCA on Sun Jul 27 16:31:52 2008

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