1s03

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{{STRUCTURE_1s03| PDB=1s03 | SCENE= }}
{{STRUCTURE_1s03| PDB=1s03 | SCENE= }}
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'''The Structure of a Ribosomal Protein S8/spc Operon mRNA Complex'''
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===The Structure of a Ribosomal Protein S8/spc Operon mRNA Complex===
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==Overview==
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In bacteria, translation of all the ribosomal protein cistrons in the spc operon mRNA is repressed by the binding of the product of one of them, S8, to an internal sequence at the 5' end of the L5 cistron. The way in which the first two genes of the spc operon are regulated, retroregulation, is mechanistically distinct from translational repression by S8 of the genes from L5 onward. A 2.8 A resolution crystal structure has been obtained of Escherichia coli S8 bound to this site. Despite sequence differences, the structure of this complex is almost identical to that of the S8/helix 21 complex seen in the small ribosomal subunit, consistent with the hypothesis that autogenous regulation of ribosomal protein synthesis results from conformational similarities between mRNAs and rRNAs. S8 binding must repress the translation of its own mRNA by inhibiting the formation of a ribosomal initiation complex at the start of the L5 cistron.
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The line below this paragraph, {{ABSTRACT_PUBMED_15146079}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15146079 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15146079}}
==About this Structure==
==About this Structure==
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[[Category: Ribosomal]]
[[Category: Ribosomal]]
[[Category: Spc operon]]
[[Category: Spc operon]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:07:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:39:11 2008''

Revision as of 00:39, 29 July 2008

Image:1s03.png

Template:STRUCTURE 1s03

The Structure of a Ribosomal Protein S8/spc Operon mRNA Complex

Template:ABSTRACT PUBMED 15146079

About this Structure

1S03 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

The structure of a ribosomal protein S8/spc operon mRNA complex., Merianos HJ, Wang J, Moore PB, RNA. 2004 Jun;10(6):954-64. PMID:15146079

Page seeded by OCA on Tue Jul 29 03:39:11 2008

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