1s10

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[[Image:1s10.gif|left|200px]]
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{{STRUCTURE_1s10| PDB=1s10 | SCENE= }}
{{STRUCTURE_1s10| PDB=1s10 | SCENE= }}
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'''Snapshots of replication through an abasic lesion: structural basis for base substitution and frameshift'''
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===Snapshots of replication through an abasic lesion: structural basis for base substitution and frameshift===
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==Overview==
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Dpo4 from S. Solfataricus, a DinB-like Y family polymerase, efficiently replicates DNA past an abasic lesion. We have determined crystal structures of Dpo4 complexed with five different abasic site-containing DNA substrates and find that translesion synthesis is template directed with the abasic site looped out and the incoming nucleotide is opposite the base 5' to the lesion. The ensuing DNA synthesis generates a -1 frameshift when the abasic site remains extrahelical. Template realignment during primer extension is also observed, resulting in base substitutions or even +1 frameshifts. In the case of a +1 frameshift, the extra nucleotide is accommodated in the solvent-exposed minor groove. In addition, the structure of an unproductive Dpo4 ternary complex suggests that the flexible little finger domain facilitates DNA orientation and translocation during translesion synthesis.
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(as it appears on PubMed at http://www.pubmed.gov), where 15023344 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15023344}}
==About this Structure==
==About this Structure==
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[[Category: Lesion bypass]]
[[Category: Lesion bypass]]
[[Category: Polymerase]]
[[Category: Polymerase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:09:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:13:09 2008''

Revision as of 21:13, 27 July 2008

Image:1s10.png

Template:STRUCTURE 1s10

Snapshots of replication through an abasic lesion: structural basis for base substitution and frameshift

Template:ABSTRACT PUBMED 15023344

About this Structure

1S10 is a Single protein structure of sequence from Sulfolobus solfataricus. Full crystallographic information is available from OCA.

Reference

Snapshots of replication through an abasic lesion; structural basis for base substitutions and frameshifts., Ling H, Boudsocq F, Woodgate R, Yang W, Mol Cell. 2004 Mar 12;13(5):751-62. PMID:15023344

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