1s12

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{{STRUCTURE_1s12| PDB=1s12 | SCENE= }}
{{STRUCTURE_1s12| PDB=1s12 | SCENE= }}
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'''Crystal structure of TM1457'''
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===Crystal structure of TM1457===
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==Overview==
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The crystal structure of a hypothetical protein, TM1457, from Thermotoga maritima has been determined at 2.0A resolution. TM1457 belongs to the DUF464 family (57 members) for which there is no known function. The structure shows that it is composed of two helices in contact with one side of a five-stranded beta-sheet. Two identical monomers form a pseudo-dimer in the asymmetric unit. There is a large cleft between the first alpha-helix and the second beta-strand. This cleft may be functionally important, since the two highly conserved motifs, GHA and VCAXV(S/T), are located around the cleft. A structural comparison of TM1457 with known protein structures shows the best hit with another hypothetical protein, Ybl001C from Saccharomyces cerevisiae, though they share low structural similarity. Therefore, TM1457 still retains a unique topology and reveals a novel fold.
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(as it appears on PubMed at http://www.pubmed.gov), where 16242963 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16242963}}
==About this Structure==
==About this Structure==
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[[Category: Psi]]
[[Category: Psi]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:09:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:20:03 2008''

Revision as of 09:20, 29 July 2008

Image:1s12.png

Template:STRUCTURE 1s12

Crystal structure of TM1457

Template:ABSTRACT PUBMED 16242963

About this Structure

1S12 is a Single protein structure of sequence from Thermotoga maritima. Full crystallographic information is available from OCA.

Reference

Crystal structure of TM1457 from Thermotoga maritima., Shin DH, Lou Y, Jancarik J, Yokota H, Kim R, Kim SH, J Struct Biol. 2005 Nov;152(2):113-7. Epub 2005 Oct 3. PMID:16242963

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