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1s2r

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{{STRUCTURE_1s2r| PDB=1s2r | SCENE= }}
{{STRUCTURE_1s2r| PDB=1s2r | SCENE= }}
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'''A High Resolution Crystal Structure of [d(CGCAAATTTGCG)]2'''
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===A High Resolution Crystal Structure of [d(CGCAAATTTGCG)]2===
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==Overview==
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The crystal structure of [d(CGCAAATTTGCG)]2 has been determined to 1.5 A resolution, representing the first high-resolution structure of this DNA fragment. The ion interactions are novel. A spermine molecule replaces a Mg2+ observed in analogous structures. Unlike lower-resolution structures, the minor groove is narrow and the major groove lacks extra Watson-Crick hydrogen bonds. In addition, a monolayer of solvent sites, including a "spine of hydration", is visible in the minor groove. The crystal of [d(CGCAAATTTGCG)]2 was grown from a solution containing spermine, magnesium, and lithium. The conformation recapitulates that of "monovalent-minus" DNA.
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(as it appears on PubMed at http://www.pubmed.gov), where 15563130 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15563130}}
==About this Structure==
==About this Structure==
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[[Category: Dodecamer]]
[[Category: Dodecamer]]
[[Category: Minor groove hydration]]
[[Category: Minor groove hydration]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:13:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:45:34 2008''

Revision as of 08:45, 29 July 2008

Image:1s2r.png

Template:STRUCTURE 1s2r

A High Resolution Crystal Structure of [d(CGCAAATTTGCG)]2

Template:ABSTRACT PUBMED 15563130

About this Structure

Full crystallographic information is available from OCA.

Reference

High-resolution structure of an extended A-tract: [d(CGCAAATTTGCG)]2., Woods KK, Maehigashi T, Howerton SB, Sines CC, Tannenbaum S, Williams LD, J Am Chem Soc. 2004 Dec 1;126(47):15330-1. PMID:15563130

Page seeded by OCA on Tue Jul 29 11:45:34 2008

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