1uvq
From Proteopedia
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| - | [[Image:1uvq. | + | [[Image:1uvq.jpg|left|200px]]<br /><applet load="1uvq" size="450" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1uvq" size="450" color="white" frame="true" align="right" spinBox="true" | + | |
caption="1uvq, resolution 1.8Å" /> | caption="1uvq, resolution 1.8Å" /> | ||
'''CRYSTAL STRUCTURE OF HLA-DQ0602 IN COMPLEX WITH A HYPOCRETIN PEPTIDE'''<br /> | '''CRYSTAL STRUCTURE OF HLA-DQ0602 IN COMPLEX WITH A HYPOCRETIN PEPTIDE'''<br /> | ||
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==Disease== | ==Disease== | ||
| - | Known diseases associated with this structure: Creutzfeldt-Jakob disease, variant, resistance to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604305 604305]], Multiple sclerosis, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604305 604305]], Narcolepsy OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=602358 602358]], Porphyria variegata OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600923 600923]] | + | Known diseases associated with this structure: Celiac disease, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604305 604305]], Creutzfeldt-Jakob disease, variant, resistance to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604305 604305]], Multiple sclerosis, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604305 604305]], Narcolepsy OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=602358 602358]], Porphyria variegata OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600923 600923]] |
==About this Structure== | ==About this Structure== | ||
| - | 1UVQ is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NAG, ZN, GLY and ACY as [http://en.wikipedia.org/wiki/ligands ligands]. | + | 1UVQ is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NAG, ZN, GLY and ACY as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:GLY Binding Site For Chain A'>AC1</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UVQ OCA]. |
==Reference== | ==Reference== | ||
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[[Category: structural proteomics in europe]] | [[Category: structural proteomics in europe]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 18:13:42 2007'' |
Revision as of 16:03, 18 December 2007
|
CRYSTAL STRUCTURE OF HLA-DQ0602 IN COMPLEX WITH A HYPOCRETIN PEPTIDE
Contents |
Overview
The MHC class II molecule DQ0602 confers strong susceptibility to, narcolepsy but dominant protection against type 1 diabetes. The crystal, structure of DQ0602 reveals the molecular features underlying these, contrasting genetic properties. Structural comparisons to homologous DQ, molecules with differential disease associations highlight a previously, unrecognized interplay between the volume of the P6 pocket and the, specificity of the P9 pocket, which implies that presentation of an, expanded peptide repertoire is critical for dominant protection against, type 1 diabetes. In narcolepsy, the volume of the P4 pocket appears, central to the susceptibility, suggesting that the presentation of a, specific peptide population plays a major role.
Disease
Known diseases associated with this structure: Celiac disease, susceptibility to OMIM:[604305], Creutzfeldt-Jakob disease, variant, resistance to OMIM:[604305], Multiple sclerosis, susceptibility to OMIM:[604305], Narcolepsy OMIM:[602358], Porphyria variegata OMIM:[600923]
About this Structure
1UVQ is a Protein complex structure of sequences from Homo sapiens with NAG, ZN, GLY and ACY as ligands. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy., Siebold C, Hansen BE, Wyer JR, Harlos K, Esnouf RE, Svejgaard A, Bell JI, Strominger JL, Jones EY, Fugger L, Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):1999-2004. Epub 2004 Feb 9. PMID:14769912
Page seeded by OCA on Tue Dec 18 18:13:42 2007
Categories: Homo sapiens | Protein complex | Bell, J.I. | Esnouf, R.E. | Fugger, L. | Hansen, B.E. | Harlos, K. | Jones, E.Y. | SPINE, Structural.Proteomics.in.Europe. | Siebold, C. | Strominger, J.L. | Svejgaard, A. | Wyer, J.R. | ACY | GLY | NAG | ZN | Autoimmune disease | Diabetes | Immunology | Mhc class ii | Narcolepsy | Spine | Structural genomics | Structural proteomics in europe
