1s3g

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{{STRUCTURE_1s3g| PDB=1s3g | SCENE= }}
{{STRUCTURE_1s3g| PDB=1s3g | SCENE= }}
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'''Crystal structure of adenylate kinase from Bacillus globisporus'''
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===Crystal structure of adenylate kinase from Bacillus globisporus===
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==Overview==
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The crystal structures of adenylate kinases from the psychrophile Bacillus globisporus and the mesophile Bacillus subtilis have been solved and compared with that from the thermophile Bacillus stearothermophilus. This is the first example we know of where a trio of protein structures has been solved that have the same number of amino acids and a high level of identity (66-74%) and yet come from organisms with different operating temperatures. The enzymes were characterized for their own thermal denaturation and inactivation, and they exhibited the same temperature preferences as their source organisms. The structures of the three highly homologous, dynamic proteins with different temperature-activity profiles provide an opportunity to explore a molecular mechanism of cold and heat adaptation. Their analysis suggests that the maintenance of the balance between stability and flexibility is crucial for proteins to function at their environmental temperatures, and it is achieved by the modification of intramolecular interactions in the process of temperature adaptation.
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{{ABSTRACT_PUBMED_15100224}}
==About this Structure==
==About this Structure==
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[[Category: Jr., G N.Phillips.]]
[[Category: Jr., G N.Phillips.]]
[[Category: Psychrophile]]
[[Category: Psychrophile]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:04:06 2008''

Revision as of 02:04, 28 July 2008

Image:1s3g.png

Template:STRUCTURE 1s3g

Crystal structure of adenylate kinase from Bacillus globisporus

Template:ABSTRACT PUBMED 15100224

About this Structure

1S3G is a Single protein structure of sequence from Sporosarcina globispora. Full crystallographic information is available from OCA.

Reference

Structures and analysis of highly homologous psychrophilic, mesophilic, and thermophilic adenylate kinases., Bae E, Phillips GN Jr, J Biol Chem. 2004 Jul 2;279(27):28202-8. Epub 2004 Apr 20. PMID:15100224

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