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1s4j

From Proteopedia

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[[Image:1s4j.gif|left|200px]]
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{{Seed}}
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[[Image:1s4j.png|left|200px]]
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{{STRUCTURE_1s4j| PDB=1s4j | SCENE= }}
{{STRUCTURE_1s4j| PDB=1s4j | SCENE= }}
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'''NMR structure of cross-reactive peptides from Homo sapiens'''
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===NMR structure of cross-reactive peptides from Homo sapiens===
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==Overview==
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The structure of peptides corresponding to the C-terminal residues from Trypanosoma cruzi (R13), human (H13) and Leishmania braziliensis (A13) ribosomal proteins were determined using nuclear magnetic resonance. Although there is only one amino acid difference between them, the peptides present distinct structures in solution: R13 adopts a random coil conformation while H13 and A13 form a bend. Interaction of these peptides with polyclonal antibodies from chronic Chagas' disease patients and a monoclonal antibody raised against T. cruzi ribosomal P2beta protein was probed by transferred NOE. The results show that the flexibility of R13 is fundamental for the binding to the antibody.
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The line below this paragraph, {{ABSTRACT_PUBMED_14988012}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14988012 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14988012}}
==About this Structure==
==About this Structure==
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1S4J is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S4J OCA].
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1S4J is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S4J OCA].
==Reference==
==Reference==
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[[Category: Chagas disease]]
[[Category: Chagas disease]]
[[Category: Ribosomal p2 protein]]
[[Category: Ribosomal p2 protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:17:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:27:35 2008''

Revision as of 16:27, 27 July 2008

Image:1s4j.png

Template:STRUCTURE 1s4j

NMR structure of cross-reactive peptides from Homo sapiens

Template:ABSTRACT PUBMED 14988012

About this Structure

1S4J is a Single protein structure. Full experimental information is available from OCA.

Reference

Correlation between conformation and antibody binding: NMR structure of cross-reactive peptides from T. cruzi, human and L. braziliensis., Soares MR, Bisch PM, Campos de Carvalho AC, Valente AP, Almeida FC, FEBS Lett. 2004 Feb 27;560(1-3):134-40. PMID:14988012

Page seeded by OCA on Sun Jul 27 19:27:35 2008

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