This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1s4w

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1s4w.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1s4w.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1s4w| PDB=1s4w | SCENE= }}
{{STRUCTURE_1s4w| PDB=1s4w | SCENE= }}
-
'''NMR structure of the cytoplasmic domain of integrin AIIb in DPC micelles'''
+
===NMR structure of the cytoplasmic domain of integrin AIIb in DPC micelles===
-
==Overview==
+
<!--
-
Cytoplasmic face-mediated integrin inside-out activation remains a paradigm in transmembrane signal transduction. Emerging evidence suggests that this process involves dissociation of the complex between the integrin cytoplasmic tails; however, a dynamic image of how it occurs on the membrane surface remains elusive. We show here that, whereas membrane-proximal helices of integrin alpha/beta cytoplasmic tails associate in cytoplasm-like aqueous medium, they become partially embedded into membrane-mimetic micelles when unclasped. Membrane embedding induces substantial structural changes of the cytoplasmic tails as compared to their aqueous conformations and suggests there may be an upward movement of the membrane-proximal helices into the membrane during their separation. We further demonstrate that the beta3 tail exhibits additional membrane binding site at its C terminus containing the NPLY motif. Talin, a key intracellular integrin activator, recognizes this site as well as the membrane-proximal helix, thereby promoting cytoplasmic tail separation along the membrane surface. These data provide a structural basis of membrane-mediated changes at the cytoplasmic face in regulating integrin activation and signaling.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15024114}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15024114 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15024114}}
==About this Structure==
==About this Structure==
-
1S4W is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S4W OCA].
+
1S4W is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S4W OCA].
==Reference==
==Reference==
Line 29: Line 33:
[[Category: Vinogradova, O.]]
[[Category: Vinogradova, O.]]
[[Category: Cell adhesion]]
[[Category: Cell adhesion]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:18:09 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:45:55 2008''

Revision as of 02:45, 29 July 2008

Image:1s4w.png

Template:STRUCTURE 1s4w

NMR structure of the cytoplasmic domain of integrin AIIb in DPC micelles

Template:ABSTRACT PUBMED 15024114

About this Structure

1S4W is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Membrane-mediated structural transitions at the cytoplasmic face during integrin activation., Vinogradova O, Vaynberg J, Kong X, Haas TA, Plow EF, Qin J, Proc Natl Acad Sci U S A. 2004 Mar 23;101(12):4094-9. Epub 2004 Mar 15. PMID:15024114

Page seeded by OCA on Tue Jul 29 05:45:55 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1s4w"
Personal tools