8yn4

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Current revision (07:05, 9 October 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8yn4 is ON HOLD until Paper Publication
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==Cryo-EM structure of histamine H2 receptor in complex with histamine and miniGq==
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<StructureSection load='8yn4' size='340' side='right'caption='[[8yn4]], [[Resolution|resolution]] 2.97&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8yn4]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8YN4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8YN4 FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.97&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=HSM:HISTAMINE'>HSM</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8yn4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8yn4 OCA], [https://pdbe.org/8yn4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8yn4 RCSB], [https://www.ebi.ac.uk/pdbsum/8yn4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8yn4 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GBB1_HUMAN GBB1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.<ref>PMID:18611381</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Synthetic construct]]
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[[Category: Gong W]]
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[[Category: Li X]]
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[[Category: Liu G]]
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[[Category: Zhang X]]

Current revision

Cryo-EM structure of histamine H2 receptor in complex with histamine and miniGq

PDB ID 8yn4

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OCA

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