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1s5r

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[[Image:1s5r.jpg|left|200px]]
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{{STRUCTURE_1s5r| PDB=1s5r | SCENE= }}
{{STRUCTURE_1s5r| PDB=1s5r | SCENE= }}
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'''Solution Structure of HBP1 SID-mSin3A PAH2 Complex'''
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===Solution Structure of HBP1 SID-mSin3A PAH2 Complex===
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==Overview==
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Recruitment of the histone deacetylase (HDAC)-associated Sin3 corepressor is an obligatory step in many eukaryotic gene silencing pathways. Here we show that HBP1, a cell cycle inhibitor and regulator of differentiation, represses transcription in a HDAC/Sin3-dependent manner by targeting the mammalian Sin3A (mSin3A) PAH2 domain. HBP1 is unrelated to the Mad1 repressor for which high-resolution structures in complex with PAH2 have been described. We show that like Mad1, the HBP1 transrepression domain binds through a helical structure to the hydrophobic cleft of mSin3A PAH2. Notably, the HBP1 helix binds PAH2 in a reversed orientation relative to Mad1 and, equally unexpectedly, this is correlated with a chain reversal of the minimal Sin3 interaction motifs. These results not only provide insights into how multiple, unrelated transcription factors recruit the same coregulator, but also have implications for how sequence similarity searches are conducted.
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(as it appears on PubMed at http://www.pubmed.gov), where 15235594 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15235594}}
==About this Structure==
==About this Structure==
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1S5R is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S5R OCA].
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1S5R is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S5R OCA].
==Reference==
==Reference==
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[[Category: Protein-peptide complex]]
[[Category: Protein-peptide complex]]
[[Category: Repressor-corepressor complex]]
[[Category: Repressor-corepressor complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:20:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:22:47 2008''

Revision as of 01:22, 28 July 2008

Image:1s5r.png

Template:STRUCTURE 1s5r

Solution Structure of HBP1 SID-mSin3A PAH2 Complex

Template:ABSTRACT PUBMED 15235594

About this Structure

1S5R is a Protein complex structure of sequences from Mus musculus. Full experimental information is available from OCA.

Reference

HBP1 and Mad1 repressors bind the Sin3 corepressor PAH2 domain with opposite helical orientations., Swanson KA, Knoepfler PS, Huang K, Kang RS, Cowley SM, Laherty CD, Eisenman RN, Radhakrishnan I, Nat Struct Mol Biol. 2004 Aug;11(8):738-46. Epub 2004 Jul 4. PMID:15235594

Page seeded by OCA on Mon Jul 28 04:22:47 2008

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