1s6r

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1s6r.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1s6r.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1s6r| PDB=1s6r | SCENE= }}
{{STRUCTURE_1s6r| PDB=1s6r | SCENE= }}
-
'''908R CLASS C BETA-LACTAMASE BOUND TO IODO-ACETAMIDO-PHENYL BORONIC ACID'''
+
===908R CLASS C BETA-LACTAMASE BOUND TO IODO-ACETAMIDO-PHENYL BORONIC ACID===
-
==Overview==
+
<!--
-
The structures of the class C beta-lactamase from Enterobacter cloacae 908R alone and in complex with a boronic acid transition-state analogue were determined by X-ray crystallography at 2.1 and 2.3 A, respectively. The structure of the enzyme resembles those of other class C beta-lactamases. The structure of the complex with the transition-state analogue, iodo-acetamido-phenyl boronic acid, shows that the inhibitor is covalently bound to the active-site serine (Ser64). Binding of the inhibitor within the active site is compared with previously determined structures of complexes with other class C enzymes. The structure of the boronic acid adduct indicates ways to improve the affinity of this class of inhibitors. This structure of 908R class C beta-lactamase in complex with a transition-state analogue provides further insights into the mechanism of action of these hydrolases.
+
The line below this paragraph, {{ABSTRACT_PUBMED_14521155}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 14521155 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_14521155}}
==About this Structure==
==About this Structure==
Line 25: Line 29:
[[Category: Wouters, J.]]
[[Category: Wouters, J.]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:22:15 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 18:46:55 2008''

Revision as of 15:46, 28 July 2008

Image:1s6r.png

Template:STRUCTURE 1s6r

908R CLASS C BETA-LACTAMASE BOUND TO IODO-ACETAMIDO-PHENYL BORONIC ACID

Template:ABSTRACT PUBMED 14521155

About this Structure

1S6R is a Single protein structure of sequence from Enterobacter cloacae. Full crystallographic information is available from OCA.

Reference

Crystal structure of Enterobacter cloacae 908R class C beta-lactamase bound to iodo-acetamido-phenyl boronic acid, a transition-state analogue., Wouters J, Fonze E, Vermeire M, Frere JM, Charlier P, Cell Mol Life Sci. 2003 Aug;60(8):1764-73. PMID:14521155

Page seeded by OCA on Mon Jul 28 18:46:55 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1s6r"
Personal tools